Scaffold-based control of chondrocyte phenotype: towards engineering of intervertebral disc tissue
نویسندگان
چکیده
Rationale There is no optimal treatment available for symptomatic degenerative disc disease which affects millions of elderly people worldwide. Most commonly used treatment modality is only symptomatic pain relief by drugs. An alternative approach is the surgical correction of intervertebral disc (IVD). Engineering of in vitro intervertebral disc composites of predefined size and shape starting from appropriate scaffolds, combined with autologous cells, has the potential to overcome the limitations associated with typical treatments.
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